I am not a male and i don't carry an anime bag. However, there are kids at my school who wear anime bags and nobody thinks twice about it. They just go on like they are the same as everyone else(and they are). You might get a couple comments at the beginning as you would with any change (Hair style, shoes, make up, clothing) but after that everyone should just accept it as you and move on. if they call you weird just say it makes you happy, if they are truly your friends then they will quickly accept it and continue to treat you how they always have.